Brandtzaeg P, Farstad I N, Haraldsen G
Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, University of Oslo, The National Hospital, Rikshospitalet, N-0027 Oslo, Norway.
Immunol Today. 1999 Jun;20(6):267-77. doi: 10.1016/s0167-5699(99)01468-1.
According to the current paradigm of lymphocyte trafficking, primed B and T cells extravasate in the intestinal lamina propria chiefly by means of the mucosal homing receptor alpha4beta7, which interacts with the vascular addressin MAdCAM-1. However, as discussed here, this mechanism cannot explain the preferential homing of B cells with a high level of J-chain expression to mucosal effector sites outside the gut.
根据目前淋巴细胞归巢的范式，致敏的B细胞和T细胞主要通过黏膜归巢受体α4β7渗出到肠道固有层，该受体与血管地址素MAdCAM-1相互作用。然而，如本文所讨论的，这种机制无法解释J链高表达的B细胞优先归巢至肠道外黏膜效应部位的现象。
