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[BRCA1 and BRCA2: mutations and other genetic changes--practical relevance].

作者信息

Scherneck S, Hofmann W

机构信息

AG Tumorgenetik, Max-Delbrück-Centrum für Molekulare Medizin (MDC) Berlin-Buch.

出版信息

Chirurg. 1999 Apr;70(4):373-9. doi: 10.1007/s001040050659.

DOI:10.1007/s001040050659
PMID:10354832
Abstract

Genetic predisposition is responsible for 5-10% of all breast cancer. Within the past 10 years the major susceptibility genes for breast cancer, BRCA1 and BRCA2, have been identified. Both genes are considered to be tumor-suppressor genes, but their function is poorly understood. Current genetic testing for mutated BRCA1 and BRCA2 is the basis for estimating disease risk for women with a strong family history of breast cancer and will provide important information on the prevention and treatment of familial breast cancer.

摘要

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C R Seances Soc Biol Fil. 1998;192(2):235-40.
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After BRCA1 and BRCA2-what next? Multifactorial segregation analyses of three-generation, population-based Australian families affected by female breast cancer.在BRCA1和BRCA2之后——接下来是什么？对受女性乳腺癌影响的澳大利亚三代人群家庭进行多因素分离分析。
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