Morita K, Adachi I, Konno M, Kubo N, Imran M B, Mochizuki T, Itoh Y, Kohya T, Kitabatake A, Tsukamoto E, Tamaki N
Department of Nuclear Medicine, Hokkaido University School of Medicine, Sapporo.
J Cardiol. 1999 May;33(5):257-63.
Electrocardiogram (ECG)-gated myocardial single photon emission computed tomography (SPECT) can assess left ventricular (LV) perfusion and function easily using quantitative gated SPECT (QGS) software. ECG-gated SPECT was performed in 44 patients with coronary artery disease under post-stress and resting conditions to assess the values of LV functional parameters, by comparison to LV ejection fraction derived from gated blood pool scan and myocardial characteristics. A good correlation was obtained between ejection fraction using QGS and that using cardiac blood pool scan (r = 0.812). Some patients with myocardial ischemia had lower ejection fraction under post-stress compared to resting conditions, indicating post-stress LV dysfunction. LV wall motion and wall thickening were significantly impaired in ischemic and infarcted myocardium, and the degree of abnormality in the infarcted areas was greater than in the ischemic area. LV functional parameters derived using QGS were useful to assess post-stress LV dysfunction and myocardial viability. In conclusion, ECG-gated myocardial SPECT permits simultaneous quantitative assessment of myocardial perfusion and function.
心电图（ECG）门控心肌单光子发射计算机断层扫描（SPECT）能够使用定量门控SPECT（QGS）软件轻松评估左心室（LV）灌注和功能。对44例冠心病患者在负荷后和静息状态下进行ECG门控SPECT，以评估LV功能参数的值，并与门控血池扫描得出的LV射血分数及心肌特征进行比较。使用QGS得出的射血分数与使用心脏血池扫描得出的射血分数之间具有良好的相关性（r = 0.812）。一些心肌缺血患者在负荷后相比静息状态下射血分数更低，表明负荷后LV功能障碍。缺血和梗死心肌的LV壁运动及壁增厚明显受损，梗死区域的异常程度大于缺血区域。使用QGS得出的LV功能参数有助于评估负荷后LV功能障碍及心肌存活性。总之，ECG门控心肌SPECT允许同时对心肌灌注和功能进行定量评估。
