Cowherd R M, Lyle R E, McGehee R E
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, USA.
Semin Cell Dev Biol. 1999 Feb;10(1):3-10. doi: 10.1006/scdb.1998.0276.
Significant advances have been made recently toward understanding the molecular events that regulate adipocyte differentiation. In vitro models of adipogenesis, such as the 3T3-L1 and F-442A preadipocyte cell lines have proven to be an invaluable resource in elucidating mechanisms of adipocyte differentiation. Subject to modulation by hormonal, dietary, and genetic influences, the differentiation program now appears to be distinctly controlled through the coordinate regulation of transcription factors that predominantly include members of the C/EBP and PPAR families. Increased understanding of these critical factors and how they are regulated will provide insights into adipose tissue development as well as treatment of obesity.
最近在理解调节脂肪细胞分化的分子事件方面取得了重大进展。脂肪生成的体外模型，如3T3-L1和F-442A前脂肪细胞系，已被证明是阐明脂肪细胞分化机制的宝贵资源。受激素、饮食和遗传影响的调节，现在分化程序似乎通过主要包括C/EBP和PPAR家族成员的转录因子的协同调节而得到明显控制。对这些关键因素及其调控方式的深入了解将为脂肪组织发育以及肥胖症治疗提供见解。
