Londos C, Brasaemle D L, Schultz C J, Segrest J P, Kimmel A R
Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-2715, USA.
Semin Cell Dev Biol. 1999 Feb;10(1):51-8. doi: 10.1006/scdb.1998.0275.
Although all animal cells package and store neutral lipids in discrete intracellular storage droplets, there is little information on the molecular processes that govern either the deposition or catabolism of the stored lipid components. Studies on adipocytes have uncovered the perilipins and ADRP, related proteins that appear to be intrinsic to the surfaces of intracellular lipid storage droplets. We discuss the properties, distribution, localization, and potential functions of these proteins, as well as those of vimentin and the recently-described 'capsular' proteins, in lipid storage and metabolism.
尽管所有动物细胞都将中性脂质包装并储存在离散的细胞内储存小滴中，但关于控制储存脂质成分沉积或分解代谢的分子过程的信息却很少。对脂肪细胞的研究发现了周脂素和脂肪分化相关蛋白（ADRP），这两种相关蛋白似乎是细胞内脂质储存小滴表面所固有的。我们讨论了这些蛋白质以及波形蛋白和最近描述的“包膜”蛋白在脂质储存和代谢中的特性、分布、定位及潜在功能。
