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[胎儿发育期间暴露于缺氧和高氧条件下肾上腺皮质的生长与功能活性]

[Growth and functional activiy of the adrenal cortex during fetal development during exposure to hypoxic and hyperoxic conditions].

作者信息

Nemets M G, Tarasova I S

出版信息

Biull Eksp Biol Med. 1976 Dec;82(12):1428-9.

PMID:1035503
Abstract

A study was made of lipid, cholesterol, and ascorbic acid content in the adrenal cortex of rabbit fetuses developing under conditions of normal pregnancy and under the action of hypoxic and hyperoxic exposures during its third trimester. It appeared that in normal pregnancy the adrenal cortex was activated, this being associated with the adaptive motor reactions of the developing fetus. The action of moderate hypoxic exposures led to a greater activation of moderate hypoxic exposures led to a greater activation of the adrenal cortex, this being expressed in a marked fall of lipid, cholesterol and ascorbic acid content. The weight of the total muscle mass and of the fetuses increased as a whole. The adrenal cortex became disactivated under conditions of the hyperoxic exposures; this is expressed in a marked increase in the content of the mentioned formations. The weight of the total mass and of the fetuses decreases.

摘要

对正常妊娠条件下以及妊娠晚期受到低氧和高氧暴露影响的兔胎儿肾上腺皮质中的脂质、胆固醇和抗坏血酸含量进行了研究。结果表明,在正常妊娠期间,肾上腺皮质被激活,这与发育中胎儿的适应性运动反应有关。适度低氧暴露的作用导致肾上腺皮质更大程度的激活,这表现为脂质、胆固醇和抗坏血酸含量显著下降。总体而言,胎儿的总肌肉质量和体重增加。在高氧暴露条件下,肾上腺皮质失活;这表现为上述物质含量显著增加。胎儿的总体质量和体重下降。

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