Charron F, Nemer M
Institut de recherches cliniques de Montréal, Laboratoire de développement et différenciation cardiaques, Québec, Canada.
Semin Cell Dev Biol. 1999 Feb;10(1):85-91. doi: 10.1006/scdb.1998.0281.
Three members of the GATA family of transcription factors, GATA-4, -5, and -6, are expressed in the developing heart. One family member, GATA-5, is restricted to the endocardium while the other two, GATA-4 and -6, are present in the myocardium where they apparently fulfil distinct functions. The mechanisms underlying GATA factor specificity are not fully understood but may involve interaction with other tissue-restricted or ubiquitous co-factors. Thus, combinatorial interaction among GATA factors or between GATA factors and other co-factors may differentially control various stages of cardiogenesis.
转录因子GATA家族的三个成员，即GATA-4、-5和-6，在心脏发育过程中表达。该家族成员之一GATA-5仅在内皮细胞中表达，而另外两个成员GATA-4和GATA-6则存在于心肌中，它们在心肌中显然发挥着不同的功能。GATA因子特异性的潜在机制尚未完全了解，但可能涉及与其他组织限制性或普遍存在的辅助因子的相互作用。因此，GATA因子之间或GATA因子与其他辅助因子之间的组合相互作用可能会差异性地控制心脏发生的各个阶段。
