口服丝裂霉素C的I期研究。
Phase I study of oral mitomycin C.
作者信息
Crooke S T, Henderson M, Samson M, Baker L H
出版信息
Cancer Treat Rep. 1976 Nov;60(11):1633-6.
PMID:1035507
Abstract
This study demonstrates that the gastrointestinal absorption of oral mitomycin C is variable and that myelosuppression correlates most closely with the peak serum concentration. The probable maximal-tolerated dose of oral mitomycin C is 45-50 mg/m2.
摘要
本研究表明，口服丝裂霉素C的胃肠道吸收存在差异，且骨髓抑制与血清峰值浓度的相关性最为密切。口服丝裂霉素C的最大耐受剂量可能为45 - 50mg/m²。
Zotero 插件