Witkowski J M
Katedra i Zakład Fizjopatologii, Akademii Medycznej w Gdańsku.
Postepy Hig Med Dosw. 1999;53(2):365-82.
An age-related dysfunction of the immune system, and especially of the T lymphocytes, is the most common feature observed during aging. It is well recognized by now that changes in the molecular mechanisms connecting the antigen receptor of the T cell with its nuclear machinery, commonly called 'signal transduction pathways' are the basis for this dysfunction. This paper is an up-to-date review of current literature of the problem, describing age-related changes in the functioning of three major, complementary pathways of signal transduction in murine and human T cell: IP3/Ca2+/calcineurin, DAG/protein kinase C (PKC) and Ras/MAP kinases, discovered so far.
免疫系统尤其是T淋巴细胞与年龄相关的功能障碍是衰老过程中最常见的特征。目前人们已经充分认识到，连接T细胞抗原受体与其核机制的分子机制变化，通常称为“信号转导通路”，是这种功能障碍的基础。本文是对该问题当前文献的最新综述，描述了迄今为止在小鼠和人类T细胞中发现的三种主要互补信号转导通路（IP3/Ca2+/钙调神经磷酸酶、二酰基甘油/蛋白激酶C (PKC) 和Ras/丝裂原活化蛋白激酶）功能与年龄相关的变化。
