[The function of voltage-gated potassium canals in T-lymphocytes under physiological and pathologic conditions].

This review focuses on biophysical properties and physiological role of voltage-gated potassium channels (named as Kv1.3) in T lymphocytes. In the first section basic electrophysiological and pharmaceutical properties of the channels have been described. Then the data on the role of the channels in setting the cell resting membrane potential, cell mitogenesis and volume regulation has been reviewed. Finally, results on patch-clamp studies on the changes in the channel expression in TL in patients suffering from chronic renal failure have been presented.