Jaiswal A K, Upadhyay S N, Satyan K S, Bhattacharya S K
Department of Pharmacology, Banaras Hindu University, Varanasi, India.
Indian J Exp Biol. 1999 Jan;37(1):17-22.
Effects of pre- and post-natal undernutrition on learning and memory parameters were studied in albino rats. Prenatal undernutrition was induced in rat pups by restricting the mother's diet by 50% during the entire gestation period, whereas postnatal undernutrition was induced in rat pups by restriction of their diet by rotating them between lactating and non-lactating maternalised females for 12 hr each day during suckling period from 2nd day to 18th day after birth. At 2.5 to 3 months of age all the rat offsprings were subjected to (i) original and reversal discrimination learning, (ii) passive avoidance, and (iii) active avoidance and its retention tests. The results indicate that both pre- and post-natal undernutrition in rat pups caused significant deficits in original and reversal discrimination learning, retention of passive avoidance after one week retention interval, and retention of active of avoidance learning. However, both pre- and post-natal undernutrition did not show significant effect on acquisition of active avoidance and retention of passive avoidance after 24 hr retention interval.
研究了产前和产后营养不良对白化大鼠学习和记忆参数的影响。通过在整个妊娠期将母鼠饮食限制50%来诱导幼鼠产前营养不良，而产后营养不良则通过在出生后第2天至第18天的哺乳期，每天将幼鼠在哺乳和非哺乳的代孕母鼠之间轮换12小时来限制其饮食来诱导。在2.5至3个月大时，所有大鼠后代都接受了以下测试：（i）原始和逆向辨别学习，（ii）被动回避，以及（iii）主动回避及其保持测试。结果表明，幼鼠的产前和产后营养不良均导致原始和逆向辨别学习、一周保持间隔后的被动回避保持以及主动回避学习保持出现显著缺陷。然而，产前和产后营养不良对24小时保持间隔后的主动回避习得和被动回避保持均未显示出显著影响。
