Au W Y, Gascoyne R D, Le N, Viswanatha D S, Klasa R J, Gallagher R, Connors J M
Division of Medical Oncology, British Columbia Cancer Agency and the University of British Columbia, Vancouver, Canada.
Ann Oncol. 1999 Mar;10(3):317-21. doi: 10.1023/a:1008328226599.
Lymphomas of mucosa associated lymphoid tissue (MALT) are a special type of extranodal lymphoma, possibly related to chronic antigenic stimulation. Increased cancer susceptibility may also contribute to the development of MALT lymphoma (MALToma). It has been suggested that patients with MALToma have an increased incidence of other malignancies.
We retrospectively reviewed the histology and clinical records of 147 patients with MALToma, including 51 cases of gastric MALToma. The incidence of any second malignancy was confirmed with a provincial registry. The relative rates of cancer, excluding MALToma, were calculated relative to the background population of the same age group and secular year.
A total of 41 tumors occurred in 32 patients (21%), including 22 solid tumors. The incidence of solid tumors in the gastric MALToma group was 15%. Seven patients had two or more second malignancies. Cancer occurred before diagnosis of MALToma in 29 cases, concurrent with MALToma in three, and after MALToma in nine. Follow-up of the surviving patients is short (median 17.6 months). The relative rate from birth of a second malignancy was 0.86 in the whole group (90% confidence interval (CI): 0.62-1.16) and 0.95 (90% CI: 0.55-1.54) in the gastric MALToma group. The rates were roughly the same if skin cancers were excluded.
The incidence of second cancers in this series is similar to previous reports. However, when compared to an age-matched population followed for the same period of time, MALToma patients do not appear to have a statistically significant increased rate of cancers.
黏膜相关淋巴组织淋巴瘤（MALT）是一种特殊类型的结外淋巴瘤，可能与慢性抗原刺激有关。癌症易感性增加也可能促使MALT淋巴瘤（MALToma）的发生。有人提出，MALToma患者发生其他恶性肿瘤的几率增加。
我们回顾性分析了147例MALToma患者的组织学和临床记录，其中包括51例胃MALToma患者。通过省级登记处确认任何第二原发性恶性肿瘤的发生率。计算除MALToma外的癌症相对发生率，以同一年龄组和同期的背景人群为参照。
32例患者（21%）共发生41种肿瘤，其中22种为实体瘤。胃MALToma组实体瘤的发生率为15%。7例患者有两种或更多种第二原发性恶性肿瘤。29例癌症发生在MALToma诊断之前，3例与MALToma同时发生，9例在MALToma之后发生。存活患者的随访时间较短（中位时间为17.6个月）。全组第二原发性恶性肿瘤自出生起的相对发生率为0.86（90%置信区间（CI）：0.62 - 1.16），胃MALToma组为0.95（90%CI：0.55 - 1.54）。如果排除皮肤癌，发生率大致相同。
本系列中第二癌症的发生率与先前报告相似。然而，与同期随访的年龄匹配人群相比，MALToma患者的癌症发生率似乎没有统计学上的显著增加。
