Yoshida K, Nakamura H
Hokkaido Igaku Zasshi. 1976 Nov;51(6):513-8.
Sixteen phenyl compounds and twenty chromane compounds substituted by geranoyl, farnesoyl, phytonoyl, retinoyl and linolenoyl synthesized by Eisai Co., Ltd were used. Male mice were fed a cholesterol or a normal basal diet which 0.3% compound was added for 10 or 31 days. Effect of these compounds on the cholesterol level of serum and liver were examined and compared to that of CPIB. As a results of this series of experiments hypocholesteremic agents were screened as follows: 3 phenyl compounds (N76009, N76011, N76012), and 6 chromane compounds (N-76-H-23, N-76-H-25, N-76-H-27, N-76-H-35, N-76-H-37, N-76-H-38). Among these compounds, N-76-H-38, (formula: see text) was found to be the most favorable cholesterol-lowering agent.
使用了由卫材株式会社合成的16种苯基化合物和20种被香叶酰基、法尼基酰基、植基、视黄酰基和亚麻酸酰基取代的色满化合物。雄性小鼠被喂食添加了0.3%化合物的胆固醇或正常基础饮食，持续10天或31天。检测了这些化合物对血清和肝脏胆固醇水平的影响，并与CPIB的影响进行比较。作为这一系列实验的结果，筛选出了如下降胆固醇药物：3种苯基化合物（N76009、N76011、N76012）和6种色满化合物（N-76-H-23、N-76-H-25、N-76-H-27、N-76-H-35、N-76-H-37、N-76-H-38）。在这些化合物中，N-76-H-38（化学式：见正文）被发现是最有利的降胆固醇药物。
