氯贝丁酯相关化合物的降血脂活性。第二篇通讯。
Hypolipemic activity of clofibrate-related compounds. 2nd Communication.
作者信息
Metz G, Specker M
出版信息
Arzneimittelforschung. 1977 Jul;27(7):1421-4.
PMID:578466
Abstract
Clofibrate-related compounds were synthesized from substituted phenoxyacetic acids by esterification with salicylic acid derivatives, by amidation of thiazolidines or by reaction with cinnarizine. Lipid lowering effect was investigated in normolipemic and hyperlipemic rats. The long-term hyperlipemic model used permits differentiation of hypolipemic efficacy, i.e., from clofibrate or compounds of similar activity.
摘要
氯贝丁酯相关化合物是通过取代苯氧乙酸与水杨酸衍生物酯化、噻唑烷酰胺化或与桂利嗪反应合成的。在正常血脂和高血脂大鼠中研究了其降脂效果。所使用的长期高血脂模型允许区分降血脂功效，即与氯贝丁酯或具有类似活性的化合物的功效区分开来。
相似文献
1
Hypolipemic activity of clofibrate-related compounds. 2nd Communication.氯贝丁酯相关化合物的降血脂活性。第二篇通讯。
Arzneimittelforschung. 1977 Jul;27(7):1421-4.
2
Hypolipemic activity of clofibrate-related compounds.氯贝丁酯相关化合物的降血脂活性。
Arzneimittelforschung. 1975 Nov;25(11):1686-92.
3
Hypolipemic activity of plafibride.普拉贝特的降血脂活性。
Arzneimittelforschung. 1981;31(10a):1796-800.
4
[Lipid depression by etofibrate in a comparative study in rats with artificial hyperlipidemia].[依托贝特在大鼠人工高脂血症比较研究中对血脂的降低作用]
Arzneimittelforschung. 1974 Dec;24(12):1990-2.
5
[Hypolipidemic activity of glycine and its derivatives].[甘氨酸及其衍生物的降血脂活性]
Vopr Med Khim. 1984 Mar-Apr;30(2):78-80.
6
7
8
9
Hypolipemic profile of plafibride in a model of experimental atherosclerosis.普拉贝特在实验性动脉粥样硬化模型中的降血脂作用
Methods Find Exp Clin Pharmacol. 1983 Nov;5(9):613-7.
Zotero 插件