Fenech M, Noakes M, Clifton P, Topping D
Commonwealth Scientific and Industrial Research Organisation, Human Nutrition, Adelaide, SA, Australia 5000.
J Nutr. 1999 Jun;129(6):1114-9. doi: 10.1093/jn/129.6.1114.
With the use of novel milling technology, it has become commercially viable to isolate the aleurone layer of cells from wheat grain and to prepare a novel flour from this fraction that has a natural folate concentration of approximately 500 microgram/100 g. The aim of this study was to determine the relative bioavailability of natural folate from aleurone flour when ingested as a cereal. Using a series of randomized, short-term intervention trials with a cross-over involving eight men and eight women aged between 29 and 50 y, we compared the increment of plasma folate following ingestion of 1) 100 g wheat bran cereal (low folate control), 2) 100 g aleurone cereal, and 3) a tablet containing 500 microgram folic acid taken together with 100 g wheat bran cereal (high folate control). Folate absorption was measured by estimating the area under the plasma folate concentration versus time curve. The extent of increase in plasma folate over the 7-hour period following ingestion of aleurone cereal was more than fourfold greater than that observed following the wheat bran cereal (P < 0.0001) and not different from that observed following the 500 microgram folic acid tablet taken with wheat bran cereal. Differences were significant when data for males and females were analyzed separately (P < 0.001). This study has shown that cereal made from wheat aleurone flour is a good source of bioavailable, natural folate.
随着新型研磨技术的应用，从小麦籽粒中分离出糊粉层细胞并由该部分制备出一种天然叶酸浓度约为500微克/100克的新型面粉在商业上已变得可行。本研究的目的是确定将糊粉层面粉作为谷物摄入时天然叶酸的相对生物利用度。通过一系列涉及8名年龄在29至50岁之间的男性和8名女性的随机短期交叉干预试验，我们比较了摄入以下物质后血浆叶酸的增加情况：1）100克麦麸谷物（低叶酸对照），2）100克糊粉层谷物，以及3）与100克麦麸谷物一起服用的含500微克叶酸的片剂（高叶酸对照）。通过估计血浆叶酸浓度与时间曲线下的面积来测量叶酸吸收。摄入糊粉层谷物后7小时内血浆叶酸增加的程度比摄入麦麸谷物后观察到的增加程度大四倍多（P<0.0001），且与与麦麸谷物一起服用500微克叶酸片剂后观察到的增加程度无差异。分别分析男性和女性的数据时差异显著（P<0.001）。本研究表明，由小麦糊粉层面粉制成的谷物是生物可利用的天然叶酸的良好来源。
