Teyler T J
Neurobiology Department, NE Ohio College of Medicine, 4209 Route 44, Rootstown, Ohio 44272-0095, USA.
Methods. 1999 Jun;18(2):109-16. doi: 10.1006/meth.1999.0764.
Brain slices have been responsible for the majority of advances in our understanding of the cellular aspects of altered synaptic strength underlying memory, long-term potentiation (LTP) and long-term depression (LTD), and increases and decreases, respectively, in synaptic strength at glutamatergic synapses. Our current understanding of LTP and LTD has come largely from studies in hippocampal slices. We consider the strengths and limitations of brain slice technology applied to this subject and conclude that they will continue to have an important role in future studies into the cellular machinery underlying changes in synaptic strength.
脑片对于我们理解记忆、长时程增强（LTP）和长时程抑制（LTD）背后突触强度改变的细胞层面，以及谷氨酸能突触处突触强度分别增加和降低方面的大多数进展都起到了作用。我们目前对LTP和LTD的理解很大程度上来自于海马体脑片的研究。我们考量了应用于该主题的脑片技术的优势和局限性，并得出结论，它们在未来对突触强度变化背后细胞机制的研究中仍将发挥重要作用。
