Maren S, Baudry M
Department of Psychology, University of California, Los Angeles 90024-1563, USA.
Neurobiol Learn Mem. 1995 Jan;63(1):1-18. doi: 10.1006/nlme.1995.1001.
Long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum are two forms of long-lasting synaptic plasticity that currently serve as our primary experimental models of learning and memory formation in mammals. In recent years, there have been considerable advances in our understanding of the cellular and molecular mechanisms of these and other forms of synaptic plasticity. This article presents an overview of these developments, considers the relationship of long-term synaptic plasticity mechanisms to learning and memory in view of these developments, and suggests future directions for research in this rapidly growing area of neuroscience.
海马体中的长时程增强（LTP）和小脑里的长时程抑制（LTD）是两种持久的突触可塑性形式，目前是我们在哺乳动物中研究学习与记忆形成的主要实验模型。近年来，我们对这些及其他形式突触可塑性的细胞和分子机制的理解有了显著进展。本文概述了这些进展，鉴于这些进展探讨了长期突触可塑性机制与学习和记忆的关系，并为这个快速发展的神经科学领域提出了未来的研究方向。
