Hamer H M, Morris H H
Department of Neurology, University of Marburg, Rudolf-Bultmann-Strasse 8, Marburg, 35039, Germany.
Seizure. 1999 May;8(3):190-2. doi: 10.1053/seiz.1998.0268.
We report three consecutive patients with hypersensitivity syndrome (HSS) due to phenytoin and carbamazepine and successful treatment with gabapentin. HSS is a rare but potentially fatal reaction to multiple drugs including several anticonvulsants. Cross-reactivity among drugs may occur. Immediate withdrawal of the offending drug is the most important step in treatment. Benzodiazepines acutely and, after resolution of the hepatitis, valproic acid have been successfully used for seizure control in patients with HSS. Our cases indicate that gabapentin is also a safe anticonvulsant in HSS.
我们报告了3例因苯妥英钠和卡马西平导致超敏反应综合征（HSS）并成功使用加巴喷丁治疗的连续病例。HSS是一种罕见但可能致命的对多种药物（包括几种抗惊厥药）的反应。药物之间可能会发生交叉反应。立即停用致病药物是治疗中最重要的步骤。苯二氮䓬类药物可急性使用，在肝炎消退后，丙戊酸已成功用于HSS患者的癫痫控制。我们的病例表明，加巴喷丁在HSS中也是一种安全的抗惊厥药。
