精神病住院患者中丙戊酸钠缓慢滴定与负荷给药不良反应的自然主义比较。
A naturalistic comparison of adverse effects between slow titration and loading of divalproex sodium in psychiatric inpatients.
作者信息
Lima W J, Dopheide J A, Kramer B A, Earhart C A, Wincor M Z
机构信息
University of Southern California, School of Pharmacy, Los Angeles, USA.
出版信息
J Affect Disord. 1999 Jan-Mar;52(1-3):261-7. doi: 10.1016/s0165-0327(98)00065-2.
BACKGROUND
This study compares the incidence, severity and onset of treatment-emergent adverse effects between slow titration and loading of divalproex sodium in psychiatric inpatients.
METHOD
Forty-seven patients were prescribed either loading or slow titration of divalproex sodium. Under single-blind conditions, adverse effects were assessed using a valproate adverse effects rating scale. Except for a statistically significant greater incidence of somnolence in the slow titration group, no statistically or clinically significant differences in incidence, severity or onset of treatment-emergent adverse effects were found between groups.
RESULTS/CONCLUSION: Overall, adverse effects were well tolerated by both groups.
背景
本研究比较了精神科住院患者中丙戊酸钠缓慢滴定法与负荷给药法在治疗中出现的不良反应的发生率、严重程度及发作情况。
方法
47例患者被给予丙戊酸钠负荷给药或缓慢滴定法。在单盲条件下，使用丙戊酸盐不良反应评定量表评估不良反应。除缓慢滴定组嗜睡发生率在统计学上显著更高外，两组在治疗中出现的不良反应的发生率、严重程度或发作情况方面未发现统计学或临床显著差异。
结果/结论：总体而言，两组对不良反应的耐受性均良好。
Zotero 插件