Dragoni F, Cartoni C, Pescarmona E, Chiarotti F, Puopolo M, Orsi E, Pignoloni P, De Gregoris C, Mandelli F
Department of Biotecnologie Cellulari ed Ematologia, Universita degli Studi La Sapienza, Rome, Italy.
Cancer. 1999 Jun 1;85(11):2485-90. doi: 10.1002/(sici)1097-0142(19990601)85:11<2485::aid-cncr26>3.0.co;2-y.
The role of high resolution pulsed and color Doppler ultrasound in the differential diagnosis of benign and malignant lymphadenopathy is still unclear.
High resolution pulsed and color Doppler ultrasound was used prospectively to investigate superficial lymph node enlargement in 71 patients undergoing surgical biopsy at the onset of lymphadenopathy. The aim of this study was to define, in multivariate analysis, the ultrasonographic parameters useful in the differential diagnosis of benign and malignant lymphadenopathy.
Volume, vascularization score, pulsatility index, and resistive index were significantly higher in the 53 malignant lymph nodes studied than in the 18 benign lymph nodes studied. The long-to-short axis ratio was significantly lower in neoplastic lymph nodes than in reactive lymph nodes. Stepwise logistic regression selected only the long-to-short axis ratio and the vascularization score as parameters that independently and significantly contributed to the differentiation of neoplastic from reactive lymph nodes. The diagnostic efficiency of the combined criteria evaluated by the area under the receiver operating characteristic curve was 0.8339.
High resolution pulsed and color Doppler ultrasound may provide information that is useful in making correct differential diagnoses of malignant or benign lymphadenopathy.
高分辨率脉冲及彩色多普勒超声在良恶性淋巴结病鉴别诊断中的作用仍不明确。
前瞻性地使用高分辨率脉冲及彩色多普勒超声对71例淋巴结病初发时接受手术活检的患者的浅表淋巴结肿大情况进行研究。本研究的目的是在多变量分析中确定有助于良恶性淋巴结病鉴别诊断的超声参数。
在研究的53个恶性淋巴结中，体积、血管化评分、搏动指数和阻力指数显著高于研究的18个良性淋巴结。肿瘤性淋巴结的长短轴比显著低于反应性淋巴结。逐步逻辑回归仅选择长短轴比和血管化评分作为独立且显著有助于区分肿瘤性与反应性淋巴结的参数。通过受试者操作特征曲线下面积评估的联合标准的诊断效率为0.8339。
高分辨率脉冲及彩色多普勒超声可能提供有助于正确鉴别恶性或良性淋巴结病的信息。
