Rader D J, Haffner S M
Department of Medicine, University of Pennsylvania Health System, University of Pennsylvania, Philadelphia 19104-2699, USA.
Am J Cardiol. 1999 May 13;83(9B):30F-35F. doi: 10.1016/s0002-9149(99)00270-2.
Elevated plasma triglyceride levels are increasingly recognized as a risk factor for cardiovascular disease. Fibric acid derivatives (fibrates) substantially decrease triglyceride levels and have been demonstrated to decrease clinical cardiovascular events in some trials. Ongoing research will elucidate the molecular mechanisms by which fibrates modify lipoprotein metabolism, clarify their use in combination with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins), and determine their role in the prevention of cardiovascular events.
血浆甘油三酯水平升高日益被视为心血管疾病的一个危险因素。纤维酸衍生物（贝特类药物）可大幅降低甘油三酯水平，并且在一些试验中已证明能减少临床心血管事件。正在进行的研究将阐明贝特类药物改变脂蛋白代谢的分子机制，明确其与3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂（他汀类药物）联合使用的情况，并确定它们在预防心血管事件中的作用。
