Kueng W, Wirz-Justice A, Menzi R, Chappuis-Arndt E
Neuroendocrinology. 1976;21(4):289-96. doi: 10.1159/000122536.
Normal 4-day cyclic rats were sacrificed at 10 a.m. and 3 p.m. on proestrus or estrus and at 10 a.m. on metestrus. Noradrenaline (NA), dopamine (DA) and tryptophan (T) concentrations varied only slightly. Serotonin (5-HT) concentrations showed characteristic changing patterns in many hypothalamic, limbic and midbrain structures with a decrease during proestrus and an increase during estrus being observed. Monoamine oxidase (MAO) activity changes were often parallel to the 5-HT changes, but were not as great. The marked changes in 5-HT early in proestrus are a further indication of its inhibitory effect on gonadotropin release mechanisms before the 'critical period'.
正常的4天周期大鼠在动情前期或发情期的上午10点和下午3点以及间情期的上午10点被处死。去甲肾上腺素（NA）、多巴胺（DA）和色氨酸（T）的浓度变化很小。血清素（5-HT）浓度在许多下丘脑、边缘系统和中脑结构中呈现出特征性的变化模式，在动情前期降低，在发情期升高。单胺氧化酶（MAO）活性变化通常与5-HT变化平行，但幅度没有那么大。动情前期早期5-HT的显著变化进一步表明其在“关键期”之前对促性腺激素释放机制具有抑制作用。
