Venero J L, Machado A, Cano J
Departamento de Bioquímica, Bromatologia y Toxicología, Facultad de Farmacia, Sevilla, Spain.
Mech Ageing Dev. 1990 Dec;56(3):253-63. doi: 10.1016/0047-6374(90)90086-u.
Levels of dopamine, noradrenaline and serotonin and their metabolites and the activities of monoamine oxidase A and B, have been determined in the prefrontal cortex of the rat during ageing. Serotonin turnover rate has been measured as 5-hydroxytryptophan accumulation rate after central decarboxylase inhibition. The major changes were an increase of dopamine and noradrenaline levels and a decrease of serotonin in aged animals compared with control animals. A decrease of the MAO-A to MAO-B ratio was found in aged rats.
在衰老过程中，已测定大鼠前额叶皮质中多巴胺、去甲肾上腺素和5-羟色胺及其代谢产物的水平，以及单胺氧化酶A和B的活性。5-羟色胺周转率通过抑制中枢脱羧酶后5-羟色氨酸的积累率来测定。与对照动物相比，老年动物的主要变化是多巴胺和去甲肾上腺素水平升高，5-羟色胺水平降低。在老年大鼠中发现单胺氧化酶A与单胺氧化酶B的比例下降。
