Benedetti W L, Sala M A, Otegui J T
Neuroendocrinology. 1976;21(4):297-303. doi: 10.1159/000122537.
Bilateral injections of 30 mug of 6-hydroxydopamine (6-OHDA, as base) into the anterolateral hypothalamic area induced constant vaginal cornification (CVC), polyfollicular ovaries and uterine hypertrophy in cyclic adult female rats. There were no important changes in the vaginal patterns or ovarian and uterine morphology in animals given injections in the same area with the solvent only and in animals given injections with 6-OHDA in the anterior amygdaloid area. It is suggested that the persistent estrus after anterolateral hypothalamic injections of 6-OHDA results from lesions of central catecholaminergic pathways, which are probably involved in gonadotropin secretion.
向成年雌性周期大鼠双侧下丘脑前外侧区注射30微克6-羟基多巴胺（6-OHDA，以碱计）可诱导持续的阴道角化（CVC）、多囊卵巢和子宫肥大。仅注射溶剂的动物以及在杏仁体前区注射6-OHDA的动物，其阴道模式、卵巢和子宫形态均无明显变化。提示下丘脑前外侧区注射6-OHDA后出现的持续发情是由中枢儿茶酚胺能通路损伤所致，这些通路可能参与促性腺激素的分泌。
