Raga F, Bonilla-Musoles F, Casañ E M, Bonilla F
Center for Obstetrics and Gynecology, Department of Obstetrics and Gynecology, University of Valencia School of Medicine and Hospital Clínico Universitario, Valencia, Spain.
Hum Reprod. 1999 Jun;14(6):1431-4. doi: 10.1093/humrep/14.6.1431.
A total of 30 young infertile patients who exhibited a poor response in two previous consecutive cycles, despite having normal basal follicle stimulating hormone (FSH) and oestradiol concentrations, were invited to participate in a prospective randomized study comparing the clinical efficacy of recombinant (rFSH) and urinary (uFSH) follicle stimulating hormone. An evaluation of the total dose used (3800 IU versus 4600 IU, P < 0.05) and duration of treatment (10.2 days versus 13.2 days, P < 0.05) showed a significantly shorter treatment period as well as a significantly lower total dose of FSH required to induce ovulation successfully in the group of patients treated with rFSH. Significantly more oocytes (7.2 versus 5. 6, P < 0.05) as well as mature oocytes (5.9 versus 3.2, P < 0.01) were retrieved after rFSH treatment. In addition, significantly more good quality embryos were obtained (3.4 versus 1.8, P < 0.05) in the group of patients treated with rFSH and, as a result, higher pregnancy (33 versus 7%, P < 0.01) and implantation (16 versus 3%, P < 0.01) rates were achieved in these patients. It is concluded that rFSH is more effective than uFSH in inducing multifollicular development and achieving pregnancy in young low responders.
共有30名年轻不孕患者，尽管其基础促卵泡激素（FSH）和雌二醇浓度正常，但在前两个连续周期中反应不佳，被邀请参加一项前瞻性随机研究，比较重组促卵泡激素（rFSH）和尿源性促卵泡激素（uFSH）的临床疗效。对使用的总剂量（3800 IU对4600 IU，P<0.05）和治疗持续时间（10.2天对13.2天，P<0.05）的评估显示，在接受rFSH治疗的患者组中，成功诱导排卵所需的治疗期明显更短，FSH总剂量也明显更低。rFSH治疗后回收的卵母细胞（7.2对5.6，P<0.05）以及成熟卵母细胞（5.9对3.2，P<0.01）明显更多。此外，接受rFSH治疗的患者组获得的优质胚胎明显更多（3.4对1.8，P<0.05），因此，这些患者的妊娠率（33%对7%，P<0.01）和着床率（16%对3%，P<0.01）更高。结论是，在诱导年轻低反应者多卵泡发育和实现妊娠方面，rFSH比uFSH更有效。
