Ferraretti A P, Gianaroli L, Magli C, Fortini D, Selman H A, Feliciani E
S.I.S.ME.R., Reproductive Medicine Unit, Via Mazzini 12, 40138, Bologna, Italy.
Hum Reprod. 1999 Jun;14(6):1457-60. doi: 10.1093/humrep/14.6.1457.
In a prospective randomized study, we analysed 125 patients at risk of ovarian hyperstimulation syndrome (OHSS), selected in the period between January 1996 and July 1997. All the patients had blood oestradiol concentration >/=1500 pg/ml on the day of human chorionic gonadotrophin (HCG) administration and >/=15 oocytes were collected. The patients were matched in two groups: group A, control group (n = 67), had fresh embryo transfers; group B (n = 58) had cryopreservation of all obtained pronucleate embryos. Pregnancy, live birth rates and the incidence of OHSS were compared between the two groups. There were no significant differences in terms of pregnancies per patient (46.3 versus 48.3%) and live birth rates (38. 8 versus 39.6%). No cases of OHSS occurred in group B, while four patients developed the syndrome in group A. The implantation rate was slightly but not significantly lower in group B (chi2 = 1.03). These results suggest that elective cryopreservation of all zygotes might prevent the risk of OHSS in patients undergoing IVF treatment. In contrast to what has been reported by other authors, our results show that the elective cryopreservation of zygotes does not affect pregnancy and live birth rates.
在一项前瞻性随机研究中，我们分析了1996年1月至1997年7月期间选取的125例有卵巢过度刺激综合征（OHSS）风险的患者。所有患者在注射人绒毛膜促性腺激素（HCG）当天血雌二醇浓度≥1500 pg/ml，且采集到≥15个卵母细胞。患者被分为两组：A组为对照组（n = 67），进行新鲜胚胎移植；B组（n = 58）对所有获得的原核胚胎进行冷冻保存。比较两组的妊娠率、活产率和OHSS发生率。两组患者的人均妊娠率（46.3%对48.3%）和活产率（38.8%对39.6%）无显著差异。B组未发生OHSS病例，而A组有4例患者发生该综合征。B组的着床率略低但无显著差异（χ2 = 1.03）。这些结果表明，对所有受精卵进行选择性冷冻保存可能会降低接受体外受精（IVF）治疗患者发生OHSS的风险。与其他作者的报道相反，我们的结果表明，对受精卵进行选择性冷冻保存不会影响妊娠率和活产率。
