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[重组因子VIIa成功治疗一名患有抑制剂的血友病儿童的血胸]

[Successful treatment of hemothorax with recombinant factor VIIa in a hemophilic child with inhibitor].

作者信息

Hulíková M, Galajda P, Kubisz P

机构信息

Regionálne centrum hemostázy a trombózy, Kosice.

出版信息

Vnitr Lek. 1998 Sep;44(9):547-50.

Abstract

rFVIIa is at present the most progressive treatment in different haemorrhages and operations in patients with haemophilia A and a high titre of inhibitor. As apparent from the presented case of a 4-year-old boy with haemorrhage into the pleural cavity, rFVIIa is sufficiently effective to induce haemostasis, while it is safe and has no side-effects. It does not induce systemic activation of haemostasis. Its application requires, due to the high price, that all criteria should be met which were elaborated for the Slovak Republic in the National centre of haemostasis and thrombosis.

摘要

重组活化凝血因子VII(rFVIIa)目前是治疗甲型血友病且抑制剂滴度高的患者在不同出血情况及手术中的最先进疗法。从所呈现的一名4岁男孩发生胸腔出血的病例可以看出,rFVIIa在诱导止血方面足够有效,同时它安全且无副作用。它不会引发全身止血激活。由于价格高昂,其应用要求必须满足斯洛伐克共和国国家止血与血栓形成中心所制定的所有标准。

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