Simpson S, Allen H, Tomenson B, Burns A
Forston Clinic, Herrison, Dorchester, United Kingdom.
J Affect Disord. 1999 May;53(2):129-36. doi: 10.1016/s0165-0327(98)00103-7.
Organic brain disease such as dementia or stroke is associated with depression. In dementia, depressive symptoms are common where there is evidence of vascular disease and in Alzheimer's disease they often coexist with extrapyramidal signs.
In a study of 60 patients with Alzheimer's disease and 39 patients with vascular dementia, depressive symptoms were rated using the Cornell Scale for Depression in Dementia. Neurological signs were assessed and severity of cognitive impairment was measured with the Mini-Mental State Examination.
Depressive symptoms were more severe in vascular dementia. Pyramidal tract signs had no relationship to depression in either type of dementia. In vascular dementia, extrapyramidal and grasp reflexes were strongly related to the severity of depression, and were associated with neurovegetative features. In Alzheimer's disease, extrapyramidal signs were the strongest independent predictor of the severity of depression.
Depressive symptoms are more severe in vascular dementia compared to Alzheimer's disease and were related to neurological abnormalities.
诸如痴呆或中风等器质性脑疾病与抑郁症有关。在痴呆症中，血管疾病证据存在时抑郁症状很常见，在阿尔茨海默病中，它们常与锥体外系体征共存。
在一项对60例阿尔茨海默病患者和39例血管性痴呆患者的研究中，使用康奈尔痴呆抑郁量表对抑郁症状进行评分。评估神经体征，并用简易精神状态检查表测量认知障碍的严重程度。
血管性痴呆中的抑郁症状更严重。锥体束征在两种类型的痴呆中均与抑郁无关。在血管性痴呆中，锥体外系和抓握反射与抑郁严重程度密切相关，并与神经植物功能特征相关。在阿尔茨海默病中，锥体外系体征是抑郁严重程度的最强独立预测因素。
与阿尔茨海默病相比，血管性痴呆中的抑郁症状更严重，且与神经学异常有关。
