Center for Imaging of Neurodegenerative Diseases, VAMC/University of California San Francisco, 4150 Clement Street, San Francisco, CA, 94121, USA.
Psychiatry Res. 2010 Feb 28;181(2):90-6. doi: 10.1016/j.pscychresns.2009.08.002. Epub 2010 Jan 13.
Depressed mood is a frequent co-morbidity of dementia suggesting that they might share a common neuropathological substrate. Gray matter (GM) atrophy and white matter lesions (WML) have been described in both conditions. Our aims were to determine the relationship of GM and WML with cognition and depressed mood in the same population. Structural brain images were obtained from 42 controls, 20 Alzheimer's disease (AD) patients and 32 subjects with cognitive impairment/dementia due to subcortical cerebrovascular disease (vascCIND/IVD). Images were segmented to obtain lobar GM, white matter and WML volumes. Lobar WML had a negative effect on GM in all lobes in controls, on frontal, parietal and occipital GM in AD and on frontal GM in vascCIND/IVD. Frontal, temporal and hippocampal GM were associated with cognitive functions and frontal WML load with depressed mood. Cognitive function is associated with GM atrophy and depressed mood is associated with frontal WML. This indicates that although both often occur together, depressed mood and cognitive impairment have different pathological correlates.
抑郁情绪是痴呆的常见合并症，表明它们可能具有共同的神经病理学基础。灰质（GM）萎缩和白质病变（WML）在这两种情况下都有描述。我们的目的是确定 GM 和 WML 与认知和抑郁情绪在同一人群中的关系。从 42 名对照组、20 名阿尔茨海默病（AD）患者和 32 名因皮质下脑血管病（vascCIND/IVD）导致认知障碍/痴呆的患者中获得了结构脑图像。对图像进行分割以获得脑叶 GM、白质和 WML 体积。在对照组中，脑叶 WML 对所有脑叶的 GM 有负面影响，对 AD 的额、顶和枕叶 GM 以及对 vascCIND/IVD 的额 GM 有负面影响。额叶、颞叶和海马 GM 与认知功能有关，而额叶 WML 负荷与抑郁情绪有关。认知功能与 GM 萎缩有关，而抑郁情绪与额叶 WML 有关。这表明，尽管两者经常同时发生，但抑郁情绪和认知障碍具有不同的病理相关性。
