Brown C, Schulberg H C, Sacco D, Perel J M, Houck P R
University of Pittsburgh School of Medicine and The Western Psychiatric Institute and Clinic, PA 15213, USA.
J Affect Disord. 1999 May;53(2):185-92. doi: 10.1016/s0165-0327(98)00120-7.
To retrospectively determine whether race differentially influences treatment adherence and clinical outcomes among 68 African Americans and 92 whites treated for major depression in four urban, primary care settings.
Study participants were randomly assigned to standardized interpersonal psychotherapy or pharmacotherapy with nortriptyline, and were assessed at baseline, and successive time points up to 8 months for severity of depression, and mental and physical health-related functioning.
Intent-to-treat analyses revealed no treatment or race-specific differences in symptomatic recovery when both groups were provided standardized psychotherapy or pharmacotherapy. However, African Americans had poorer functional outcomes than whites.
African American and white primary medical care patients are effectively treated with standardized psychotherapy and pharmacotherapy. Future research should assess the impact of cultural context on symptom presentation, psychosocial functioning, and treatment adherence and response.
回顾性研究在四个城市初级医疗环境中接受重度抑郁症治疗的68名非裔美国人和92名白人中，种族是否对治疗依从性和临床结果有不同影响。
研究参与者被随机分配接受标准化人际心理治疗或去甲替林药物治疗，并在基线以及长达8个月的连续时间点评估抑郁严重程度以及与心理和身体健康相关的功能。
意向性分析显示，当两组都接受标准化心理治疗或药物治疗时，在症状恢复方面没有治疗或种族特异性差异。然而，非裔美国人的功能结果比白人差。
非裔美国人和白人初级医疗患者通过标准化心理治疗和药物治疗可得到有效治疗。未来的研究应评估文化背景对症状表现、心理社会功能、治疗依从性和反应的影响。
