Nakajima K, Ito Z, Hen R, Uemura K, Matsuoka S
No To Shinkei. 1976 Feb;28(2):197-201.
It is well known that congenital anomalies such as polycystic kidney, aortic coarctation, Marfan syndrome, Ehler-Danlos syndrome are apt to be complicated by intracranial aneurysms. In this report we attempt to reveal the relation and incidence between cerebrovascular anomalies and intracranial aneurysms. The etiology of aneurysms has been discussed, too. 12 cases of persistent trigeminl artery, 2 cases of persistent hypoglossal artery and 11 cases of fenestration were obtained from 3841 patients who were angiographically examined in our clinic for 5 years. The incidence is 0.31%, 0.05% and 0.29%, respectively. Persistent trigeminal arteries were complicated by 2 cases of intracranial aneurysms and one case of arterivenous malformations (AVM), persistent hypoglossal arteries were complicated by one case of aneurysm, and fenestrations were complicated by 2 cases of aneurysms and one case of AVM. One case of congenital agenesis of right internal carotid artery was obtained which was complicated by aneurysm of anterior communicating artery. Totally, 8 cases of aneurysms and AVM were obtained from 26 cases of cerebrovascular anomalies (incidence 30.8%). On the other hand, thalamic or caudate hemorrhage revealed the highest incidence of complication of intracranial aneurysms among intracerebral hematomas (10.7%). Compared with the incidence of aneurysms between cerebro vascular anomalies (30.8%) and thalamic or caudate hemorrhage (10.7%), the difference is statistically signigicant (P less than 0.05). The cause of intracranial aneurysm has not yet been clarified. But it is well accepted that the defect of tunica media vasorum is most responsible factor as to the occurrence of intracranial aneurysms. We concluded that the genetic error of cerebral vessels including defect of media caused intracranial aneurysms, and this result was supported from the evidence that cerebrovascular anomalies showed statistically high incidence of complication of intracranial aneurysms.
众所周知，多囊肾、主动脉缩窄、马方综合征、埃勒斯-当洛综合征等先天性异常容易并发颅内动脉瘤。在本报告中，我们试图揭示脑血管异常与颅内动脉瘤之间的关系及发生率。同时也讨论了动脉瘤的病因。从我院5年期间接受血管造影检查的3841例患者中，发现12例持续性三叉动脉、2例持续性舌下动脉和11例血管开窗。发生率分别为0.31%、0.05%和0.29%。持续性三叉动脉并发2例颅内动脉瘤和1例动静脉畸形（AVM），持续性舌下动脉并发1例动脉瘤，血管开窗并发2例动脉瘤和1例AVM。发现1例右侧颈内动脉先天性发育不全，并发前交通动脉瘤。在26例脑血管异常中共发现8例动脉瘤和AVM（发生率30.8%）。另一方面，丘脑或尾状核出血在脑内血肿中并发颅内动脉瘤的发生率最高（10.7%）。比较脑血管异常（30.8%）和丘脑或尾状核出血（10.7%）的动脉瘤发生率，差异有统计学意义（P＜0.05）。颅内动脉瘤的病因尚未阐明。但人们普遍认为，血管中层缺陷是颅内动脉瘤发生的最主要因素。我们得出结论，包括中层缺陷在内的脑血管遗传错误导致了颅内动脉瘤，这一结果得到了以下证据的支持，即脑血管异常并发颅内动脉瘤的发生率在统计学上较高。
