来自RANTES氨基末端序列的低分子量抗HIV-1肽：共受体导向抗HIV-1药物的潜在先导化合物。

Low-molecular-weight anti-HIV-1 peptides from the amino-terminal sequence of RANTES: possible lead compounds for coreceptor-directed anti-HIV-1 agents.

作者信息

Nishiyama Y, Murakami T, Kurita K, Yamamoto N

机构信息

Department of Industrial Chemistry, Faculty of Engineering, Seikei University, Tokyo, Japan.

出版信息

Bioorg Med Chem Lett. 1999 May 17;9(10):1357-60. doi: 10.1016/s0960-894x(99)00204-8.

DOI:10.1016/s0960-894x(99)00204-8

PMID:10360735

Abstract

A series of small peptides corresponding to the amino-terminal sequence of RANTES were synthesized, and their anti-HIV-1 activity was evaluated. Pentapeptides, H-(10Ala-RANTES 6-10)-OH and Ac-(10Ala-RANTES 6-10)-NH2, were the smallest anti-HIV-1 peptides so far developed, and would be potentially important lead compounds for coreceptor-directed anti-HIV-1 drugs.

摘要

合成了一系列与RANTES氨基末端序列相对应的小肽，并评估了它们的抗HIV-1活性。五肽H-(10Ala-RANTES 6-10)-OH和Ac-(10Ala-RANTES 6-10)-NH2是迄今为止开发出的最小的抗HIV-1肽，可能是共受体导向抗HIV-1药物的重要先导化合物。