甲硫氨酰腺苷酸类似物作为甲硫氨酰 - tRNA合成酶的抑制剂
Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase.
作者信息
Lee J, Kang S U, Kang M K, Chun M W, Jo Y J, Kwak J H, Kim S
机构信息
Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, Korea.
出版信息
Bioorg Med Chem Lett. 1999 May 17;9(10):1365-70. doi: 10.1016/s0960-894x(99)00206-1.
Four stable analogues of methionyl adenylate (3-6) were designed as inhibitors of methionyl-tRNA synthetase and synthesized from 2',3'-isopropylideneadenosine. They strongly inhibited aminoacylation activity of methionyl-tRNA synthetases isolated from Escherichia coli, Mycobacterium tuberculosis, Saccharomyces cerevisiae and human. Among the microorganisms tested, however, these chemicals showed the growth inhibition effect only on E. coli.
设计了四种稳定的甲硫氨酰腺苷类似物（3-6）作为甲硫氨酰-tRNA合成酶的抑制剂，并由2'，3'-异丙叉腺苷合成。它们强烈抑制从大肠杆菌、结核分枝杆菌、酿酒酵母和人类中分离出的甲硫氨酰-tRNA合成酶的氨酰化活性。然而，在所测试的微生物中，这些化学物质仅对大肠杆菌显示出生长抑制作用。
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