结构基因组学的进展。

Advances in structural genomics.

作者信息

Teichmann S A, Chothia C, Gerstein M

机构信息

MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK.

出版信息

Curr Opin Struct Biol. 1999 Jun;9(3):390-9. doi: 10.1016/S0959-440X(99)80053-0.

DOI:10.1016/S0959-440X(99)80053-0

PMID:10361097

Abstract

New computational techniques have allowed protein folds to be assigned to all or parts of between a quarter (Caenorhabditis elegans) and a half (Mycoplasma genitalium) of the individual protein sequences in different genomes. These assignments give a new perspective on domain structures, gene duplications, protein families and protein folds in genome sequences.

摘要

新的计算技术已能够将蛋白质折叠指定给不同基因组中四分之一（秀丽隐杆线虫）至二分之一（生殖支原体）的单个蛋白质序列的全部或部分。这些指定为基因组序列中的结构域结构、基因复制、蛋白质家族和蛋白质折叠提供了新的视角。