Sato M, Onishi T, Nakashima T, Otsuki S
No To Shinkei. 1976 Jul;28(7):667-79.
The seizure development was investigated in seven septal kindled cats for examining a participation of septal area in psychomotor epilepsy. Daily electrical stimulation (mean: 33.5 days) of septal area could lead to the "kindled" generalized convulsion. Six stages of behavioral seizure development were distinguished: 1) attention reaction, 2) the above and immobility, 3) the above and autonomic manifestation, 4) the above and facial twitching, head nodding, 5) the above and tonic extension of contralateral forepaw, 6) the above and generalized clonic convulsions. Self-sustained after-discharge and independent interictal spike discharge appeared in the hippocampus in stage 2 or 3, in the amygdala and the globus pallidus in stage 3 or 4, and also in the ventromedial hypothalamic nucleus in stage 5. Positive transference phenomenon was confirmed in bilateral hippocampus, amygdala and globus pallidus. These findings show the progressive dissemination of secondary epileptogeneses in these secondary brain structures during the septal seizure development. Electrographic and behavioral seizure development mentioned above were completely identical to those in the hippocampal seizure that we have reported previously. It is concluded that psychomotor epilepsies may not only be triggered by the hippocampal and amygdaloid foci but by the septum and its related structuresfoei.
为研究隔区在精神运动性癫痫中的作用，对7只隔区点燃猫的癫痫发作发展情况进行了研究。每日对隔区进行电刺激（平均33.5天）可导致“点燃”的全身性惊厥。行为性癫痫发作发展分为六个阶段：1）注意力反应，2）上述表现及不动，3）上述表现及自主神经表现，4）上述表现及面部抽搐、点头，5）上述表现及对侧前肢强直性伸展，6）上述表现及全身性阵挛性惊厥。在第2或3阶段，海马中出现自发放电后放电和独立的发作间期棘波放电，在第3或4阶段，杏仁核和苍白球中出现，在第5阶段，腹内侧下丘脑核中也出现。在双侧海马、杏仁核和苍白球中证实了阳性转移现象。这些发现表明，在隔区癫痫发作发展过程中，继发性癫痫灶在这些继发性脑结构中进行性扩散。上述脑电图和行为性癫痫发作发展与我们之前报道的海马癫痫发作完全相同。结论是，精神运动性癫痫可能不仅由海马和杏仁核病灶触发，还可由隔区及其相关结构病灶触发。
