Marinoni E, Di Iorio R, Letizia C, Villaccio B, Alberini A, Cosmi E V
2nd Institute of Obstetrics and Gynecology, and Department of Internal Medicine, University La Sapienza, Rome, Italy.
Obstet Gynecol. 1999 Jun;93(6):964-7. doi: 10.1016/s0029-7844(98)00551-1.
To determine whether adrenomedullin levels in amniotic fluid were associated with preterm labor.
We measured immunoreactive adrenomedullin in amniotic fluid collected by amniocentesis from 36 women with clinical diagnosis of preterm labor or preterm premature rupture of membranes (PROM) and from 18 normal pregnant women.
Amniotic fluid from cases of PROM and failure to respond to tocolysis were associated significantly with higher amniotic fluid adrenomedullin concentrations (177.0 +/- 22.5 pg/mL and 182.7 +/- 22.0 pg/mL, respectively, P < .01) than that from uncomplicated pregnancies (101.2 +/- 28.1 pg/mL) or preterm labor responsive to tocolysis (102.3 +/- 26.8 pg/mL).
Amniotic fluid adrenomedullin is higher than normal in cases of PROM and preterm labor unresponsive to tocolysis, perhaps indicating enhanced synthesis from placenta or fetal membranes being stimulated by bacterial products.
确定羊水中心房钠尿肽水平是否与早产相关。
我们通过羊膜穿刺术收集了36例临床诊断为早产或胎膜早破（PROM）的孕妇以及18例正常孕妇的羊水，检测其中免疫反应性心房钠尿肽。
胎膜早破病例及对宫缩抑制剂无反应者的羊水心房钠尿肽浓度显著高于未并发妊娠（101.2±28.1 pg/mL）或对宫缩抑制剂有反应的早产者（102.3±26.8 pg/mL）（分别为177.0±22.5 pg/mL和182.7±22.0 pg/mL，P<.01）。
胎膜早破及对宫缩抑制剂无反应的早产病例中羊水心房钠尿肽高于正常，这可能表明胎盘或胎膜受到细菌产物刺激后合成增强。
