Khan K S, Chien P F, Dwarakanath L S
Academic Department of Obstetrics and Gynecology, University of Birmingham, United Kingdom.
Obstet Gynecol. 1999 Jun;93(6):1014-20. doi: 10.1016/s0029-7844(98)00537-7.
To evaluate the reporting of multivariable logistic regression analyses and assess variations in quality over time in the obstetrics and gynecology literature.
Methodologic criteria for reporting logistic regression analyses were developed to identify problems affecting accuracy, precision, and interpretation of this approach to multivariable statistical analysis. These criteria were applied to 193 articles that reported multivariable logistic regression in the issues of four generic obstetrics and gynecology journals in 1985, 1990, and 1995. Rates of compliance with the methodologic criteria and their time trends were analyzed.
The proportion of articles using logistic regression analysis increased over time: 1.7% in 1985, 2.8% in 1990, and 6.5% in 1995 (P < .001 for trend). Violations and omissions of methodologic criteria for reporting logistic models were common. The research question, in terms of dependent and independent variables, was not clearly reported in 32.1%. The process of variable selection was inadequately described in 51.8% of the articles. Among articles with ranked independent variables, 85.1% did not report assessment of conformity to linear gradient. Tests for goodness of fit were not given in 93.2% of articles. The contribution of the independent variables could not be evaluated in 36.2% of the articles because of a lack of coding of the variables. Interactions between variables were not assessed in 86.4% of articles. Analysis of variations in the quality of logistic regression analyses over time showed no increase in reporting of the criteria concerning variable selection and goodness of fit. However, the proportion of articles reporting one quality criterion concerning interpretation of the substantive significance of independent variables showed a trend toward improvement: 42.3% in 1985, 73.6% in 1990, and 75.4% in 1995 (P = .004 for trend).
The reporting of multivariable logistic regression models in the obstetrics and gynecology literature is poor, and the time trends of improvement in quality of reporting are not particularly encouraging.
评估多变量逻辑回归分析的报告情况，并评估妇产科文献中报告质量随时间的变化。
制定了报告逻辑回归分析的方法学标准，以识别影响这种多变量统计分析方法的准确性、精确性和解释的问题。将这些标准应用于1985年、1990年和1995年四种通用妇产科杂志上发表的193篇报告多变量逻辑回归的文章。分析了符合方法学标准的比例及其时间趋势。
使用逻辑回归分析的文章比例随时间增加：1985年为1.7%，1990年为2.8%，1995年为6.5%（趋势P <.001）。违反和遗漏逻辑模型报告方法学标准的情况很常见。在32.1%的文章中，关于因变量和自变量的研究问题没有清晰报告。51.8%的文章对变量选择过程描述不充分。在具有排序自变量的文章中，85.1%未报告对线性梯度一致性的评估。93.2%的文章未给出拟合优度检验。由于缺乏变量编码，36.2%的文章无法评估自变量的贡献。86.4%的文章未评估变量之间的相互作用。对逻辑回归分析质量随时间变化的分析表明，关于变量选择和拟合优度的标准报告没有增加。然而，报告一项关于自变量实质性意义解释的质量标准的文章比例呈改善趋势：1985年为42.3%，1990年为73.6%，1995年为75.4%（趋势P =.004）。
妇产科文献中多变量逻辑回归模型的报告质量较差，报告质量改善的时间趋势并不特别令人鼓舞。
