Baschinsky D Y, Frankel W L, Niemann T H
Department of Pathology, The Ohio State University Hospital, Columbus, USA.
Am J Gastroenterol. 1999 Jun;94(6):1678-81. doi: 10.1111/j.1572-0241.1999.01162.x.
Extraskeletal neoplasms with osteoclast-like giant cells are uncommon. These tumors are most frequently reported in the breast and pancreas, and are relatively rare in other sites. We report a case of primary gastric adenocarcinoma with an infiltrate of osteoclast-like giant cells. The patient is a 64-yr-old black woman who presented with epigastric pain and was found to have a mass in the gastric antrum. Histological examination showed a poorly differentiated adenocarcinoma with an infiltrate of osteoclast-like giant cells. The giant cells were present both in the primary gastric adenocarcinoma and in the lymph node metastases. Immunohistochemical stains demonstrated that the giant cells were of monocytic/histiocytic origin and probably represent a distinctive host response to the tumor. The patient is alive and well 12 months after resection. This is the second published report of gastric carcinoma with osteoclast-like giant cells. Based on this limited experience, gastric carcinoma with osteoclast-like giant cells may represent a distinct clinicopathological entity with a more favorable prognosis.
伴有破骨细胞样巨细胞的骨外肿瘤并不常见。这些肿瘤最常报道于乳腺和胰腺，在其他部位相对少见。我们报告一例原发性胃腺癌伴有破骨细胞样巨细胞浸润。患者为一名64岁的黑人女性，因上腹部疼痛就诊，发现胃窦部有一肿块。组织学检查显示为低分化腺癌伴有破骨细胞样巨细胞浸润。巨细胞存在于原发性胃腺癌及淋巴结转移灶中。免疫组化染色显示巨细胞起源于单核细胞/组织细胞，可能代表了机体对肿瘤的一种独特反应。患者术后12个月仍存活且状况良好。这是第二例关于伴有破骨细胞样巨细胞的胃癌的报道。基于这一有限的经验，伴有破骨细胞样巨细胞的胃癌可能代表一种具有更良好预后的独特临床病理实体。
