Akatsu Tomotaka, Kameyama Kaori, Kawachi Shigeyuki, Tanabe Minoru, Aiura Koichi, Wakabayashi Go, Ueda Masakazu, Shimazu Motohide, Kitajima Masaki
Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
J Gastroenterol. 2006 Jan;41(1):83-7. doi: 10.1007/s00535-005-1726-5.
Extraskeletal tumors containing multinucleated, osteoclast-like giant cells (OGCs) are uncommon. These neoplasms are most frequently reported in the breast and pancreas. Recently, some authors have suggested that carcinomas containing OGCs may represent a distinct clinicopathological entity with a more favorable prognosis. Occurrence in the gallbladder is extremely rare, with only one previous case. We report here on an additional case of gallbladder carcinoma with an infiltrate of OGCs. A 72-year-old woman presented with postprandial abdominal pain and was found to have a mass in the body of the gallbladder with direct liver invasion. Histological examination showed an adenosquamous carcinoma with an infiltrate of benign OGCs. Immunohistochemical analysis demonstrated that the giant cells were of histiocytic origin. The patient survived for 6 years without evidence of recurrence. This case adds to a small body of literature on gallbladder carcinoma with OGCs. Further studies are required to clearly define the prognostic significance of these giant cells in gallbladder cancer and the differences between adenosquamous carcinoma with OGCs and other gallbladder carcinomas (such as adenocarcinoma and squamous cell carcinoma) with those cells.
含有多核破骨细胞样巨细胞（OGCs）的骨外肿瘤并不常见。这些肿瘤最常报道于乳腺和胰腺。最近，一些作者认为含有OGCs的癌可能代表一种具有更有利预后的独特临床病理实体。发生在胆囊极为罕见，此前仅有一例报道。我们在此报告另一例伴有OGCs浸润的胆囊癌病例。一名72岁女性因餐后腹痛就诊，发现胆囊体部有一肿块并直接侵犯肝脏。组织学检查显示为腺鳞癌伴良性OGCs浸润。免疫组化分析表明巨细胞起源于组织细胞。该患者存活6年，无复发迹象。此病例补充了关于伴有OGCs的胆囊癌的少量文献。需要进一步研究以明确这些巨细胞在胆囊癌中的预后意义，以及伴有OGCs的腺鳞癌与其他伴有这些细胞的胆囊癌（如腺癌和鳞状细胞癌）之间的差异。
