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甲氨蝶呤成功治疗中枢神经系统多中心混合性淋巴瘤。

Successful therapy with methotrexate of a multicentric mixed lymphoma of the central nervous system.

作者信息

Herbst K D, Corder M P, Justice G R

出版信息

Cancer. 1976 Oct;38(4):1476-8. doi: 10.1002/1097-0142(197610)38:4<1476::aid-cncr2820380405>3.0.co;2-j.

DOI:10.1002/1097-0142(197610)38:4<1476::aid-cncr2820380405>3.0.co;2-j
PMID:1036465
Abstract

Primary lymphoma of the central nervous system (CNS) is extremely rare. A case of mixed histiocytic lymphocytic lymphoma of the CNS that initially occurred in the spinal cord is reported. Multicentric recurrence following radiotherapy was successfully treated with intrathecal methotrexate and the patient remains free of disease after 4 years. The role of intrathecal methotrexate as alternative therapy following irradiation failure is discussed.

摘要

中枢神经系统原发性淋巴瘤极为罕见。本文报告一例最初发生于脊髓的中枢神经系统混合组织细胞淋巴细胞淋巴瘤病例。放疗后多中心复发，通过鞘内注射甲氨蝶呤成功治疗，患者4年后仍无疾病复发。本文还讨论了鞘内注射甲氨蝶呤在放疗失败后作为替代疗法的作用。

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