Foubert L, Mareels K, den Blauwen N, Herregods L, Rolly G
Department of Anaesthesia, University Hospital, Gent, Belgium.
Anaesthesia. 1999 Mar;54(3):220-5. doi: 10.1046/j.1365-2044.1999.00702.x.
We examined the possibility that predilution of a concentrated nitric oxide (NO) source with nitrogen, before contact with oxygen, can reduce the inspired nitrogen dioxide (NO2) concentration during administration of nitric oxide. A Manley Blease and a Siemens Servo 900 C ventilator delivered 10, 20, 40, 60 and 80 parts per million (ppm) NO using an NO source of 1000, 400 and 200 ppm. With the Manley Blease system, predilution from 1000 to 200 ppm NO reduced the inhaled NO2 concentration from 0.14 to 0.05 ppm (p < 0.01) at 10 ppm inhaled NO, and from 1.20 to 1.00 ppm (p < 0.01) at 40 ppm inhaled NO. With the Siemens Servo 900 C ventilator, inspiratory NO2 concentrations decreased from 0.21 to 0.11 ppm (p < 0.01) at 10 ppm inhaled NO, and from 1.49 to 1.16 ppm (p < 0.01) at 40 ppm NO. Predilution from 1000 to 400 ppm NO reduced the inspired NO2 concentrations by < 3% using either ventilator when the inspirated NO concentration was 80 ppm. Predilution of NO with nitrogen significantly reduced the inspired NO2 concentrations for nitric oxide concentrations between 10 and 40 ppm, but offered no clinically relevant advantage at higher NO concentrations.
我们研究了在浓一氧化氮（NO）源与氧气接触之前用氮气进行预稀释，是否能够在一氧化氮给药过程中降低吸入的二氧化氮（NO₂）浓度。一台曼利·布利斯（Manley Blease）呼吸机和一台西门子Servo 900 C呼吸机使用1000 ppm、400 ppm和200 ppm的NO源输送百万分之10、20、40、60和80（ppm）的NO。对于曼利·布利斯系统，将NO从1000 ppm预稀释至200 ppm时，吸入NO浓度为10 ppm时，吸入的NO₂浓度从0.14 ppm降至0.05 ppm（p < 0.01）；吸入NO浓度为40 ppm时，从1.20 ppm降至1.00 ppm（p < 0.01）。对于西门子Servo 900 C呼吸机，吸入NO浓度为10 ppm时，吸气时的NO₂浓度从0.21 ppm降至0.11 ppm（p < 0.01）；吸入NO浓度为40 ppm时，从1.49 ppm降至1.16 ppm（p < 0.01）。当吸入的NO浓度为80 ppm时，使用任一呼吸机将NO从1000 ppm预稀释至400 ppm，吸入的NO₂浓度降低< 3%。用氮气对NO进行预稀释可显著降低10至40 ppm一氧化氮浓度时吸入的NO₂浓度，但在较高NO浓度时无临床相关优势。
