非那雄胺治疗男性前额型雄激素性脱发
Finasteride in the treatment of men with frontal male pattern hair loss.
作者信息
Leyden J, Dunlap F, Miller B, Winters P, Lebwohl M, Hecker D, Kraus S, Baldwin H, Shalita A, Draelos Z, Markou M, Thiboutot D, Rapaport M, Kang S, Kelly T, Pariser D, Webster G, Hordinsky M, Rietschel R, Katz H I, Terranella L, Best S, Round E, Waldstreicher J
机构信息
University of Pennsylvania School of Medicine, Philadelphia, USA.
出版信息
J Am Acad Dermatol. 1999 Jun;40(6 Pt 1):930-7. doi: 10.1016/s0190-9622(99)70081-2.
BACKGROUND
Finasteride, a specific inhibitor of type II 5alpha-reductase, decreases serum and scalp dihydrotestosterone and has been shown to be effective in men with vertex male pattern hair loss.
OBJECTIVE
This study evaluated the efficacy of finasteride 1 mg/day in men with frontal (anterior/mid) scalp hair thinning.
METHODS
This was a 1-year, double-blind, placebo-controlled study followed by a 1-year open extension. Efficacy was assessed by hair counts (1 cm2 circular area), patient and investigator assessments, and global photographic review.
RESULTS
There was a significant increase in hair count in the frontal scalp of finasteride-treated patients (P < .001), as well as significant improvements in patient, investigator, and global photographic assessments. Efficacy was maintained or improved throughout the second year of the study. Finasteride was generally well tolerated.
CONCLUSION
In men with hair loss in the anterior/mid area of the scalp, finasteride 1 mg/day slowed hair loss and increased hair growth.
背景
非那雄胺是II型5α-还原酶的特异性抑制剂，可降低血清和头皮中的二氢睾酮水平，已证明对头顶男性型脱发男性有效。
目的
本研究评估了每天1毫克非那雄胺对前额（前部/中部）头皮头发稀疏男性的疗效。
方法
这是一项为期1年的双盲、安慰剂对照研究，随后进行为期1年的开放扩展研究。通过毛发计数（1平方厘米圆形区域）、患者和研究者评估以及整体照片评估来评估疗效。
结果
非那雄胺治疗患者的前额头皮毛发计数显著增加（P <.001），患者、研究者和整体照片评估也有显著改善。在研究的第二年，疗效得以维持或提高。非那雄胺总体耐受性良好。
结论
对于头皮前部/中部脱发的男性，每天1毫克非那雄胺可减缓脱发并促进头发生长。
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