Price Vera H, Menefee Emory, Sanchez Matilde, Ruane Patrick, Kaufman Keith D
University of California, San Francisco, CA, USA.
J Am Acad Dermatol. 2002 Apr;46(4):517-23. doi: 10.1067/mjd.2002.120537.
Finasteride, a type II 5alpha-reductase inhibitor, reduces scalp and serum dihydrotestosterone and has been shown to be effective in men with androgenetic alopecia (AGA).
The purpose of this study was to determine the effect of finasteride on scalp hair weight in men with AGA.
Sixty-six men with AGA received finasteride, 1 mg/d, or placebo in a 48-week study, and 49 men continued in a 48-week extension. Efficacy was assessed by scalp hair weights and hair counts.
As expected, hair counts improved with finasteride (net mean percent change +/- SE [95% CI] compared with placebo = 9.2% +/- 2.8% [3.8, 14.6] and 15.4% +/- 3.2% [9.1, 21.7] at 48 and 96 weeks, respectively; P <.01 for both time points), and net improvements in hair weight were greater (25.6% +/- 3.6% [18.5, 32.7] and 35.8% +/- 4.6% [26.7, 44.8] at 48 and 96 weeks, respectively; P <.001 for both time points). Finasteride was generally well tolerated.
In this study, finasteride, 1 mg, increased hair weight in men with AGA. Hair weight increased to a larger extent than hair count, implying that factors other than the number of hairs, such as increased growth rate (length) and thickness of hairs, contribute to the beneficial effects of finasteride in treated men.
非那雄胺是一种II型5α-还原酶抑制剂，可降低头皮和血清中的二氢睾酮，已被证明对雄激素性脱发（AGA）男性有效。
本研究旨在确定非那雄胺对AGA男性头皮毛发重量的影响。
66名AGA男性在一项为期48周的研究中接受1mg/d的非那雄胺或安慰剂治疗，49名男性继续进行为期48周的延长期研究。通过头皮毛发重量和毛发计数评估疗效。
正如预期的那样，非那雄胺治疗后毛发计数有所改善（与安慰剂相比，48周和96周时净平均变化百分比±标准误[95%置信区间]分别为9.2%±2.8%[3.8, 14.6]和15.4%±3.2%[9.1, 21.7]；两个时间点P均<.01），毛发重量的净改善更大（48周和96周时分别为25.6%±3.6%[18.5, 32.7]和35.8%±4.6%[26.7, 44.8]；两个时间点P均<.001）。非那雄胺总体耐受性良好。
在本研究中，1mg非那雄胺增加了AGA男性的毛发重量。毛发重量的增加幅度大于毛发计数，这意味着除毛发数量外，其他因素，如毛发生长速度（长度）和厚度的增加，对非那雄胺治疗男性的有益效果有贡献。
