眼眶和眼睑的巨细胞血管纤维瘤
Giant cell angiofibroma of the orbit and eyelid.
作者信息
Hayashi N, Borodic G, Karesh J W, Tolentino M J, Remulla H D, Van Wesep R A, Grossniklaus H E, Jakobiec F A, Green W R
机构信息
Wilmer Ophthalmological Institute, and Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
出版信息
Ophthalmology. 1999 Jun;106(6):1223-9. doi: 10.1016/S0161-6420(99)90270-1.
PURPOSE
To report the clinicopathologic features of a newly recognized tumor, giant cell angiofibroma.
DESIGN
Observational case series.
MAIN OUTCOME MEASURES
Clinical and histopathologic features of giant cell angiofibroma.
METHODS
Light and electron microscopy and immunohistochemistry of five cases of giant cell angiofibroma.
RESULTS
A total of five patients (4 women and 1 man) are described: two presented with a painless mass in the eyelid, two with a mass in the orbit, and one presented with a conjunctival lesion. All lesions were well demarcated with no capsule and were composed of blood vessels, a patternless spindle-shaped cell proliferation with a solid and pseudovascular appearance, and multinucleated giant cells. Both spindle-shaped and giant tumor cells were intensely positive for CD34 and vimentin.
CONCLUSION
Giant cell angiofibroma resembles solitary fibrous tumor and giant cell fibroblastoma and should be considered in the differential diagnosis of spindle-cell tumors in the eyelid, orbit, and conjunctiva.
目的
报告一种新发现的肿瘤——巨细胞血管纤维瘤的临床病理特征。
设计
观察性病例系列。
主要观察指标
巨细胞血管纤维瘤的临床及组织病理学特征。
方法
对5例巨细胞血管纤维瘤进行光镜、电镜及免疫组织化学检查。
结果
共描述了5例患者（4例女性，1例男性）：2例表现为眼睑无痛性肿块，2例表现为眼眶肿块，1例表现为结膜病变。所有病变边界清晰，无包膜，由血管、无规律的梭形细胞增殖构成，呈实性和假血管外观，以及多核巨细胞。梭形细胞和巨细胞瘤细胞CD34和波形蛋白均呈强阳性。
结论
巨细胞血管纤维瘤类似于孤立性纤维性肿瘤和巨细胞成纤维细胞瘤，在眼睑、眼眶和结膜梭形细胞肿瘤的鉴别诊断中应予以考虑。
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