[帕金森病的神经内分泌方面。催乳素抑制剂的治疗作用]
[Neuroendocrine aspects of Parkinson's disease. Therapeutic/effect of a prolactin inhibitor].
作者信息
Agnoli A, Casacchia M, Carolei A, Meco G, Zamponi A, Ruggieri S
出版信息
Minerva Med. 1976 Nov 3;67(53).
PMID:1036612
Abstract
On the basis of a reassessment of the aetiopathogenetic problem and the neuroendocrine implications, the therapeutic effectiveness of a prolactin inhibitor, 2-alpha-Br-ergocryptine (CB 154), in Parkinson's disease is assessed. Five patients were treated for a total of two weeks using doses between 10 and 15 mg/die. CB 154 was found to act as a dopaminergic receptor agonist at nigro-striatal level, considerably improving tremor and rigidity and to a lesser extent bradykinesia and total disability.
摘要
基于对病因发病机制问题及神经内分泌影响的重新评估，对一种催乳素抑制剂2-α-溴麦角隐亭（CB 154）在帕金森病中的治疗效果进行了评估。5名患者使用剂量为10至15毫克/日，共治疗两周。发现CB 154在黑质纹状体水平作为多巴胺能受体激动剂起作用，可显著改善震颤和僵直，对运动迟缓及整体残疾的改善程度较小。
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