erb-b2免疫染色在宫颈癌中的意义。
The significance of Erb-b2 immunostaining in cervical cancer.
作者信息
Nevin J, Laing D, Kaye P, McCulloch T, Barnard R, Silcocks P, Blackett T, Paterson M, Sharp F, Cruse P
机构信息
Department of Gynaecological Oncology, University of Cape Town, Cape Town, South Africa.
出版信息
Gynecol Oncol. 1999 Jun;73(3):354-8. doi: 10.1006/gyno.1999.5396.
OBJECTIVE
The aim of this study was to assess the relationship between survival and erb-b2 immunohistochemical staining in patients with early stage cervical carcinoma.
METHODS
Archival specimens for 126 patients with stage IB/IIA cervical carcinoma treated with radical hysterectomy and bilateral pelvic node dissection (RH-BPND) were retrieved and submitted to immunohistochemistry for ERBB2 expression. The association between positive results and poor survival was assessed in a multivariate analysis.
RESULTS
Erb-b2 immunostaining was significantly associated with poor survival (P = 0.0284) but less so than parametrial extension (P = 0.0014) and nodal disease (P = 0.0106). Tumor type (squamous/adenosquamous/adenocarcinoma) and the status of surgical margins were not significantly associated with survival.
CONCLUSIONS
These results supported further investigations of ERBB2 expression as a marker of high-risk disease in patients treated with RH-BPND.
目的
本研究旨在评估早期宫颈癌患者的生存率与erb-b2免疫组化染色之间的关系。
方法
检索126例接受根治性子宫切除术和双侧盆腔淋巴结清扫术（RH-BPND）治疗的IB/IIA期宫颈癌患者的存档标本，并进行ERBB2表达的免疫组化检测。在多因素分析中评估阳性结果与生存率低之间的关联。
结果
erb-b2免疫染色与生存率低显著相关（P = 0.0284），但相关性低于宫旁组织浸润（P = 0.0014）和淋巴结疾病（P = 0.0106）。肿瘤类型（鳞状/腺鳞/腺癌）和手术切缘状态与生存率无显著相关性。
结论
这些结果支持进一步研究ERBB2表达作为接受RH-BPND治疗患者高危疾病标志物的可能性。
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