Schultze A E, Mason G L, Clyde V L
Department of Pathology, College of Veterinary Medicine, University of Tennessee, Knoxville 37901-1071, USA.
J Zoo Wildl Med. 1999 Mar;30(1):158-64.
A 6-mo-old male Savannah monitor lizard (Varanus exanthematicus) was presented for lethargy and anorexia of 7 days duration. Physical examination revealed a slightly raised subcutaneous mass (1 cm diameter) in the left scapular area. Fine-needle aspiration cytology of the mass revealed a population of immature, pleomorphic lymphoid cells consistent with lymphosarcoma. A hemogram indicated marked leukocytosis (465,000 cells/microl) characterized by extreme lymphocytosis and many circulating lymphoid blast cells. The lizard was euthanized at the owner's request. Necropsy revealed severe hepatomegaly and multiple raised, ulcerated mural masses in the gastrointestinal tract. There were many raised, poorly demarcated tan foci in all the parenchymal organs. Histopathologic examination confirmed infiltration of all parenchymal organs by neoplastic lymphoid cells. Transmission electron microscopic examination failed to identify viruses within the neoplastic cells. A literature review revealed few reports of squamate leukemia and lymphosarcoma and none in Savannah monitor lizards.
一只6个月大的雄性萨凡纳巨蜥（草原巨蜥）因持续7天的嗜睡和厌食前来就诊。体格检查发现左肩胛区有一个略隆起的皮下肿块（直径1厘米）。对该肿块进行细针穿刺细胞学检查，发现一群不成熟的、多形性的淋巴细胞，符合淋巴肉瘤的特征。血常规显示白细胞显著增多（465,000个/微升），其特征为极度淋巴细胞增多和许多循环中的淋巴母细胞。应主人要求，对这只蜥蜴实施了安乐死。尸检发现严重肝肿大，胃肠道有多个隆起的、溃疡的壁层肿块。所有实质器官都有许多隆起的、边界不清的黄褐色病灶。组织病理学检查证实肿瘤性淋巴细胞浸润了所有实质器官。透射电子显微镜检查未能在肿瘤细胞内发现病毒。文献回顾显示，关于有鳞目白血病和淋巴肉瘤的报道很少，在萨凡纳巨蜥中尚无此类报道。
