Ramírez-Weber F A, Kornberg T B
Department of Biochemistry and Biophysics, University of California, San Francisco 94143, USA.
Cell. 1999 May 28;97(5):599-607. doi: 10.1016/s0092-8674(00)80771-0.
Wing imaginal disc cells in Drosophila develop by using information received from a signaling center associated with the anterior/posterior compartment border. We show here that disc cells have thin, actin-based extensions (cytonemes) that project to this signaling center. Cytonemes can be induced when cells from the lateral flanks of a wing disc are cultured next to cells from the A/P border or next to a source of fibroblast growth factor. Mouse limb bud cells also grow projections during a brief culture period, indicating that cytonemes are an attribute of both vertebrate and invertebrate cells. We suggest that cytonemes may be responsible for some forms of long-range cell-cell communication.
果蝇的翅成虫盘细胞通过利用从前/后隔室边界相关信号中心接收的信息来发育。我们在此表明，盘细胞具有基于肌动蛋白的细延伸物（细胞线），其伸向该信号中心。当翅成虫盘侧翼的细胞与来自前/后边界的细胞或成纤维细胞生长因子源相邻培养时，可诱导细胞线的形成。小鼠肢芽细胞在短暂培养期也会生长出突起，这表明细胞线是脊椎动物和无脊椎动物细胞共有的特征。我们认为，细胞线可能负责某些形式的长距离细胞间通讯。
