对麻疹、腮腺炎和风疹疫苗有全身性速发型和非速发型反应的儿童中针对明胶的特异性IgG 。
Specific IgG to gelatin in children with systemic immediate- and nonimmediate-type reactions to measles, mumps and rubella vaccines.
作者信息
Miyazawa H, Saitoh S, Kumagai T, Yamanaka T, Yasuda S, Tsunetsugu-Yokota Y, Inouye S, Sakaguchi M
机构信息
Department of Medical Technology, Kyorin University, Hachiohji, Tokyo, Japan.
出版信息
Vaccine. 1999 Apr 23;17(17):2176-80. doi: 10.1016/s0264-410x(98)00368-5.
We examined anti-gelatin IgG in sera of children who suffered from systemic adverse reactions upon immunization with gelatin-containing live virus vaccines. In the group of 30 children who had immediate-type reactions and anti-gelatin IgE, 30 (100%) had anti-gelatin IgG and 29 (96%) had anti-gelatin IgG4. In another group of 75 children who had nonimmediate-type reactions and no anti-gelatin IgE, 22 (29%) had anti-gelatin IgG and six (8%) had IgG4. The IgG positivity well correlated with the lymphocyte proliferation assay positivity. In contrast, as a negative control, all 24 children who had no allergic reaction to live virus vaccines had no anti-gelatin IgG and IgG4. The results suggest that immune-response to gelatin may play a role in the pathogenesis of systemic nonimmediate-type reactions to the live virus vaccines.
我们检测了在接种含明胶的活病毒疫苗后出现全身不良反应的儿童血清中的抗明胶IgG。在30名有速发型反应且有抗明胶IgE的儿童组中，30名（100%）有抗明胶IgG，29名（96%）有抗明胶IgG4。在另一组75名有非速发型反应且无抗明胶IgE的儿童中，22名（29%）有抗明胶IgG，6名（8%）有IgG4。IgG阳性与淋巴细胞增殖试验阳性密切相关。相比之下，作为阴性对照，所有24名对活病毒疫苗无过敏反应的儿童均无抗明胶IgG和IgG4。结果表明，对明胶的免疫反应可能在活病毒疫苗全身非速发型反应的发病机制中起作用。
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