对日本脑炎疫苗出现全身性皮肤反应的儿童中针对明胶的特异性IgE和IgG
Specific IgE and IgG to gelatin in children with systemic cutaneous reactions to Japanese encephalitis vaccines.
作者信息
Sakaguchi M, Miyazawa H, Inouye S
机构信息
Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan.
出版信息
Allergy. 2001 Jun;56(6):536-9. doi: 10.1034/j.1398-9995.2001.056006536.x.
BACKGROUND
Systemic allergic reactions to Japanese encephalitis (JE) vaccine that include urticaria, angioedema, and rash have been reported. In Japan, children who suffered from allergic immediate-type reactions to JE vaccine had antigelatin IgE in their sera. However, the immunologic mechanism of allergic nonimmediate-type reactions that consist of cutaneous signs appearing several hours or more after JE vaccination has not been defined.
METHODS
Serum samples were taken from 28 children who showed allergic nonimmediate-type cutaneous reactions to JE vaccine. Furthermore, serum samples were taken from 10 children who showed allergic immediate-type reactions with cutaneous signs and/or respiratory symptoms to JE vaccine. We have defined an immediate-type reaction as one occurring within 1 h after vaccination.
RESULTS
Of 10 children who showed immediate-type reactions, all had antigelatin IgE and IgG. Of 28 children who showed systemic nonimmediate-type reactions, one had antigelatin IgE and nine (32%) had antigelatin IgG. The child who had antigelatin IgE showed urticaria 2 h after JE vaccination.
CONCLUSION
These results suggest that some children who showed allergic nonimmediate-type reactions to JE vaccine were sensitized to gelatin.
背景
已有报告称日本脑炎（JE）疫苗会引发全身性过敏反应，包括荨麻疹、血管性水肿和皮疹。在日本，对JE疫苗产生过敏性速发型反应的儿童血清中含有抗明胶IgE。然而，由JE疫苗接种数小时或更长时间后出现的皮肤症状组成的过敏性迟发型反应的免疫机制尚未明确。
方法
采集了28名对JE疫苗表现出过敏性迟发型皮肤反应的儿童的血清样本。此外，还采集了10名对JE疫苗表现出伴有皮肤症状和/或呼吸道症状的过敏性速发型反应的儿童的血清样本。我们将速发型反应定义为接种疫苗后1小时内发生的反应。
结果
在表现出速发型反应的10名儿童中，所有儿童均有抗明胶IgE和IgG。在表现出全身性迟发型反应的28名儿童中，1名儿童有抗明胶IgE，9名（32%）儿童有抗明胶IgG。有抗明胶IgE的儿童在接种JE疫苗2小时后出现荨麻疹。
结论
这些结果表明，一些对JE疫苗表现出过敏性迟发型反应的儿童对明胶敏感。
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